Leo Bersamina was born in San Francisco, California and grew up predominantly on the coast, just south of the city. Bersamina began studying studio art in Santa Cruz, California. Later he attended San Francisco State University to finish his BA with an emphasis in Studio Art. He then received an MFA in Painting at Yale School of Art in New Haven, Connecticut.
Upon graduation from Yale, he lived in New York City. Bersamina later returned to California to teach Studio Art at UC Berkeley. He also has taught at Yale, Stanford, Pont-Aven School of Contemporary Art, Santa Rosa Junior College, and Diablo Valley College (where he currently is a full-time instructor). Bersamina continues to exhibit nationally and internationally, and currently resides just north of San Francisco.